Ref-1 and Transcriptional Control of Endothelial Apoptosis
نویسندگان
چکیده
منابع مشابه
Ref-1 and transcriptional control of endothelial apoptosis.
Vascular endothelium, when unperturbed, provides a surface to the blood vessel, which is passive to the development of thrombosis, and potentially adherent blood cells. This characteristic is the quintessence of vascular homeostasis.1 However, endothelial cells (ECs) can undergo apoptosis in vitro in response to a variety of pathophysiological conditions including hypoxia, proinflammatory cytok...
متن کاملTranscriptional and translational control of Mcl-1 during apoptosis.
Mcl-1 is an antiapoptotic member of the Bcl-2 family whose protein and mRNA have a short half-life. In this report, we studied the changes in Mcl-1 protein and mRNA expression induced by staurosporine and aspirin. Both drugs induced apoptosis in Jurkat cells and reduced the levels of Mcl-1 protein. The caspase inhibitor Z-VAD.fmk and the proteasome inhibitor MG132 partially protected Mcl-1 from...
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Pancreatic cancer is a largely incurable disease, and increasing evidence supports strategies targeting multiple molecular mediators of critical functions of pancreatic ductal adenocarcinoma cells. Intracellular redox state modulates the activity of various signal transduction pathways and biological processes, including cell survival, drug resistance and responsiveness to microenvironmental fa...
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OBJECTIVE Human Hepatocellular Carcinoma (HCC) is the fifth most frequent neoplasm worldwide and the most serious complication of long-standing chronic liver diseases (CLD). Its development is associated with chronic inflammation and sustained oxidative stress. Deregulation of apurinic apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1), a master regulator of cellular response to o...
متن کاملEndothelial cell tumor growth is Ape/ref-1 dependent.
Tumor-forming endothelial cells have highly elevated levels of Nox-4 that release H2O2 into the nucleus, which is generally not compatible with cell survival. We sought to identify compensatory mechanisms that enable tumor-forming endothelial cells to survive and proliferate under these conditions. Ape-1/ref-1 (Apex-1) is a multifunctional protein that promotes DNA binding of redox-sensitive tr...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2001
ISSN: 0009-7330,1524-4571
DOI: 10.1161/hh1201.093162